Speaker: Margarita Kruteva, FZ Jülich, Germany

The Antibodies in Solution: a LINXS – NIST Webinar Series provides background information related to the currently ongoing LINXS antibody research program. This is a concerted experimental and theoretical effort that aims to investigate the properties of monoclonal antibodies in solution, which comprise a major platform for potential drug candidates and are of high academic and pharmaceutical interest. An international consortium of researchers at academic institutions, research centers, NIST and Novartis has teamed up for this. Didactical lectures given by members of the consortium on different experimental and theoretical topics that are highly relevant for state-of-the-art antibody research as well as insights from pharmaceutical industry will be broadcasted. A central aspect of the webinar series will be to illustrate the full power of neutron and X-ray scattering science that can be achieved in combination with complementary experimental methods and different unifying simulation techniques.

Abstract:

Diffusion NMR complements quasielasic neutron scattering (QENS) technique at tens to hundreds millisecond time scale covering the length scale of order of a few micrometers. One of the most powerful techniques is the pulsed field gradient (PFG) NMR providing the self-diffusion constant. In my talk I will present a few examples of synergy of QENS and PFG NMR to study the polymeric and bio-macromolecular systems. In particular, the diffusion of the monoclonal Antibodies in a complex environment will be addressed.