Sign up for a 2-day mini-symposium on neutron diffraction in drug discovery, design and formulation (7-8 May), followed by an afternoon tour at European Spallation Source in Lund (8 May)!

Title: Neutron scattering in drug discovery, design, and formulation

When: 7–8 May, 2024, including buffet dinner at LINXS (7/5) and a visit to European Spallation Source (8/5)

Where: Workshop room on the 5th floor of LINXS (Scheelevägen 19, Lund) or online via Zoom. Physical participation is encouraged!

Fees and registration information:

Please indicate in the registration if you would like to join the dinner in the evening and the guided tour at ESS.

• Physical participation: 700 SEK

• Online participation: 350 SEK

EXTENDED DEADLINE! Please note that the registration deadline for the tour at ESS is 2/5.

Abstracts: There will be an opportunity to submit an abstract for a contributed talk. If you wish to have a talk, please send your abstract to raminta.venskutonyte@med.lu.se after completing the registration.

Walking Tour at European Spallation Source: Please note that there is a limited number of spots available for a walking tour of the experimental halls and deuteration labs. All those interested need to register by 2/5. Participants need to bring a picture ID for security purposes and also wear long trousers and closed shoes since we will be entering an active construction site.

---

Invited speakers

---

Program

May 7

12:00–13:00 Lunch and registration

13:00–13:10 Welcome and introduction

13:10–13:50 “Investigating structure and performance in lipid nanocarriers”, Hanna Barriga, Karolinska Institute, Stockholm

13:50–14:20 "Update on the Large-Scale Structures Instruments at ESS”, Thomas Arnold, European Spallation Source, Sweden

14:20–15:00  "Studies of hydrogen bonding in galectin-3 using neutron crystallography can aid drug design", Derek Logan, Lund University, Sweden

15:00–15:20 Coffee break

15:20–15:50 “DEMAX: the deuteration and crystallization support platform at ESS”, Zoë Fisher, European Spallation Source, Sweden

15:50–16:30 “Interactions at the lipid-aqueous interface – a key factor for drug delivery using lipid nanoparticles”, Tommy Nylander, Lund University

16:30–17:10 “The catalytic mechanism of the SARS CoV 2 Macrodomain and how to inhibit it”, James Fraser (via Zoom), UCSF School of Pharmacy, USA

17:30– Mingle followed by a buffet dinner at LINXS

May 8

08:45–09:15 Arrival and coffee/buns

09:15–09:55 “Structural investigation of lipid nanoparticle is key to improve mRNA delivery“, Federica Sebastiani, University of Copenhagen, Denmark

09:55–10:35 “A new view into the mechanism of apoptosis-regulating Bcl-2 proteins in mitochondrial membrane mimics using neutron reflection”, Hanna Wacklin-Knecht, European Spallation Source, Sweden

10:35–10:50 Coffee break

10:50–11:30 “How deep is your drug-depth-resolved drug interactions with lipid bilayers using neutrons”, Nicolo Paracini (via Zoom), Institut Laue-Langevin, France

11:30–12:00 Contributed talk

12:00–12:10 Final remarks and practicalities for the ESS visit

12:10–13:00 Lunch at LINXS

Travel to ESS

13:30–15:00 Safety instructions and tour at ESS

15:00–16:00 Coffee and Q&A

---

Organisers

The main organiser of the event is Raminta Venskutonyte raminta.venskutonyte@med.lu.se

For practical questions about the workshop, please contact josefin.martell@linxs.lu.se

---

During our events we sometimes take photographs and short film clips to profile our activities. Please let us know if you don’t want to be in any photos/films before we start the event. Some webinars are recorded to be used for educational purposes in the LINXS website.

By registering to our events you give your permission to LINXS, according to the General Data Protection Regulation (GDPR), to register your name and e-mail address to be used for the sole purpose of distributing newsletters and communications on LINXS activities.

If you don’t receive registration confirmation please check your spam mail.